The keyboard shortcuts are quite nice, but I also heavily use Gmail's keyboard shortcuts, and one discrepancy frequently trips me up:
C: complete (RTM)/compose (Gmail)
Y: notes (RTM)/archive(Gmail)

I assume there's no way I'm talking you into changing the default shortcuts for RTM, but how about giving me a setting to tweak them for myself? I'd make Y complete (similar to Gmail's archive functionality) and pick something else for notes.